Endocrine Abstracts

Introduction: Acromegaly is a rare pathology characterized by chronic hypersecretion of Growth Hormone (GH) and Insulin-like Growth Factor-1 (IGF-1) that causes somatic, metabolic, and systemic changes. There are few data in the literature on the impact of the disease in male.Patients and methods: Retrospective descriptive study including 15 adult males with acromegaly hospitalized in the endocrinology department of the Hedi Chaker Sfax university hospit...

Introduction: Pheochromocytoma represents only 5% of adrenal incidentalomas. It is malignant in only 10% of cases. We report a case of pheochrompcytoma with suspucion of double cortico-meullary component or an ectopic secretion of CRH in the context of neurofibromatosis type1Observation: A26year old woman with a history of unilateral renal lithiasis, colic and breast neoplasia, with no notable personal history, consulted for right lumbar pain. An abdomin...

Introduction: Addison disease is associated with high risk of fractures and low bone mineral density. Causes are complex, including supraphysiologic glucocorticoid replacement therapy and concomitant autoimmune disorders. The aim of our study is to assess the influence of glucorticoid replacement therapy on bone mineral density in patients with Addison disease.Patients and methods: Descriptive and analytical cross- sectional study including 50 patients w...

Introduction: Mitochondrial diabetes (DM) is a monogenic form of maternal transmission diabetes that is caused by mutations in the mitochondrial genome. These mutations affecting mitochondrial function may be the cause of initiation of the phenomenon of apoptosis itself having an aggravating role of the phenotype in patients with mitochondrial diabetes.Materials and Methods: This study involved 43 patients with mitochondrial diabetes (20 non-syndromic an...

Introduction: Sexual disorders 46 XY DSD are responsible for a range of phenotypic disorders, ranging from an ambiguous phenotype to a complete female phenotype. In this context, we report a cohort of 22 46 XY patients with a female phenotype in order to establish a phenotype-genotype correlation.Results: The average age at diagnosis was 15.5 years (E: 7 days-33 years). The reason for consultation was primary amenorrhea in 16 cases (72.7%), sexual ambigu...

Background and Aims: The incidence of adrenal incidentaloma(AI) has been rising sharply due to the increased use of radiologic imaging. It shows evident variation with age, with the majority of the cases presenting in the 5th to 7th decade of life. This study aims to assess the prevalence of AI and its radiological features and hormonal profiles in the geriatric population.Patients and Method: We conducted a retrospective descriptive study including 177 ...

Introduction: In adults with Addison disease, over glucocorticoid replacement therapy is associated with an increased morbidity and decreased life expectancy, related to low bone mineral density and cardiometabolic outcomes. The aim of our study was to assess the prevalence of carbohydrate metabolism disorders in patients with Addison disease and identify its predictive factors.Patients and methods: A cross sectional study including 50 patients diagnosed...

Introduction: Long-term glucocorticoid replacement therapy in patients with Addison disease has been linked to an increased cardiovascular risk and consequent mortality. Our objective was to determine the frequency of dyslipidemia in patients with Addison disease and its potential predictive factors.Patients and methods: This was a cross-sectional study, performed in the department of endocrinology in Hedi Chaker hospital –Sfax –Tunisia. Fifty ...

Introduction: Inadequate glucocorticoid replacement therapy in Addison disease leads to an increased risk of both cardiovascular disease and metabolic syndrome. The metabolic effects of long-life corticosteroid exposure are due to physiological mechanisms that are associated with carbohydrate metabolism disorder, dyslipidemia and insulin resistance. In this study, we aimed to determine the prevalence and predictive factors of metabolic syndrome in patients with Addison disease...

Background and Aims: Growing scientific evidence supports the hypothesis of an increased cardiometabolic risk in patients harboring adrenal incidentalomas (AI). This risk would be higher in aging populations and patients with functioning adenomas. The current study aims to determine the clinical and biochemical characteristics of metabloic syndrome(MetS) and assess its prevalence in older patients with AI.Patients and Method: We conducted a retrospective...